c-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking
نویسندگان
چکیده
Veronika E Neubrand, Rainer D Will, Wiebke Möbius, Annemarie Poustka, Stefan Wiemann, Peter Schu, Carlos G Dotti, Rainer Pepperkok* and Jeremy C Simpson Cell Biology and Cell Biophysics Programme, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, Molecular Genome Analysis, German Cancer Research Centre, Heidelberg, Germany, Max Planck Institute for Experimental Medicine, Neurogenetics, Göttingen, Germany, Zentrum fuer Biochemie und Molekulare Zellbiologie, Department Biochemie II, Universitaet Göttingen, Goettingen, Germany and Cavalieri Ottolenghi Scientific Institute, Unversita degli Studi di Torino, AO San Luigi Gonzaga, Orbassano (Torino), Italy
منابع مشابه
Arabidopsis μ-adaptin subunit AP1M of adaptor protein complex 1 mediates late secretory and vacuolar traffic and is required for growth.
Adaptor protein (AP) complexes are the predominant coat proteins of membrane vesicles in post-Golgi trafficking of mammalian cells. Each AP complex contains a specific medium subunit, μ-adaptin, that selects cargo proteins bearing sequence-specific sorting motifs. Much less is known about the AP complexes and their μ subunits in plants. Because of uncertain homology, the μ-adaptins of Arabidops...
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We had previously identified the mutant allele of apm1(+) that encodes a homolog of the mammalian μ 1A subunit of the clathrin-associated adaptor protein-1 (AP-1) complex and demonstrated that the AP-1 complex plays a role in Golgi/endosome trafficking, secretion, and vacuole fusion in fission yeast. Here, we isolated a mutant allele of its4(+)/sip1(+), which encodes a conserved AP-1 accessory ...
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Rho family GTPases act as molecular switches to regulate a range of physiological functions, including the regulation of the actin-based cytoskeleton, membrane trafficking, cell morphology, nuclear gene expression, and cell growth. Rho function is regulated by its ability to bind GTP and by its localization. We previously demonstrated functional and physical interactions between Rho3 and the cl...
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Plant vacuoles are versatile organelles critical for plant growth and responses to environment. Vacuolar proteins are transported from the endoplasmic reticulum via multiple routes in plants. Two classic routes bear great similarity to other phyla with major regulators known, such as COPII and Rab5 GTPases. By contrast, vacuolar trafficking mediated by adaptor protein-3 (AP-3) or that independe...
متن کاملAdaptor Protein-3-Dependent Vacuolar Trafficking Involves a Subpopulation of COPII and HOPS Tethering Proteins1[OPEN]
Plant vacuoles are versatile organelles critical for plant growth and responses to environment. Vacuolar proteins are transported from the endoplasmic reticulum via multiple routes in plants. Two classic routes bear great similarity to other phyla with major regulators known, such as COPII and Rab5 GTPases. By contrast, vacuolar trafficking mediated by adaptor protein-3 (AP-3) or that independe...
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